tumor necrosis factor-related apoptosis-inducing ligand gene polymorphisms and hepatitis b virus infection

conclusions according to our result, 1525g/a and 1595c/t were in strong linkage disequilibrium and the polymorphisms of the trail gene in the 3’ utr region were not associated with the outcome of hbv infection. results our data showed that genotypes 1525g/a and 1595c/t were in complete linkage disequilibrium and the genotype frequencies at the two positions were the same. no significant differences in frequencies of genotype and alleles at positions 1525g/a and 1595c/t were observed between all the three groups (p value > 0.05). patients and methods polymerase chain reaction-based restriction fragment length polymorphism (pcr–rflp) was applied to genotype trail polymorphisms at positions 1525g/a and 1595c/t. to evaluate the trail gene polymorphism in the 3’ utr region at position 1525g/a and 1595c/t, 147 patients with hbv infection were divided into three different groups of chronic hepatitis (n = 52), cirrhosis (n = 33), and carrier (n = 62) and there was a group of 101 healthy controls. objectives this study was carried out to determine the role of the trail gene polymorphisms in clinical outcome of hbv infection. background tumor necrosis factor-related apoptosis-inducing ligand (trail) is an apoptotic molecule with a key role in the apoptosis of tumors and virus-infected cells. the association of 1525g/a and 1595c/t polymorphisms in the region of 3’ utr on the trail gene has been shown in many cancers and diseases. polymorphism at the positions of 1525g/a and 1595c/t might influence the clearance of hepatitis b virus (hbv).